Linked Life Data

8017839

Source:http://linkedlifedata.com/resource/pubmed/id/8017839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
1994-7-25
pubmed:abstractText
Two multidrug-resistant breast cancer cell lines (MCF-7/AdrVp and MCF-7/D.40) each expressing a different membrane protein, involved in the drug resistance, have been treated with a transferrin-doxorubicin conjugate. Conjugates have shown an increase of activity over free doxorubicin on these resistant cell lines. Growth inhibition of doxorubicin-resistant cells, as evaluated by the MTT-assay, was higher for conjugates than for free doxorubicin especially for a 4-day contact period. I D 50 were twice and 10-fold lower for the conjugate than for free doxorubicin on resistant cells. MCF-7/AdrVp seemed to be particularly affected by the conjugate even if its intracellular content of doxorubicin was similar. With the Trf-Dox conjugate, an inverted correlation does exist between the drug-DNA content and the cytotoxicity of the conjugate. Verapamil influenced the uptake of free doxorubicin but not the uptake of Trf-Dox conjugate, thus showing a different mechanism of entry.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-403
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Sensitivity of multidrug-resistant MCF-7 cells to a transferrin-doxorubicin conjugate.
pubmed:affiliation
Department of Biochemistry, Faculty of Medicine, Université Laval, Québec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't