| pubmed-article:8016145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8016145 | lifeskim:mentions | umls-concept:C0919528 | lld:lifeskim |
| pubmed-article:8016145 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:8016145 | lifeskim:mentions | umls-concept:C0332597 | lld:lifeskim |
| pubmed-article:8016145 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:8016145 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:8016145 | pubmed:dateCreated | 1994-7-28 | lld:pubmed |
| pubmed-article:8016145 | pubmed:abstractText | The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations present in 5-10% of human acute leukemias. We have recently reported the detection by Southern blot of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations. These include 2 of 19 patients with normal karyotypes as well as 3 of 4 patients with trisomy 11. To characterize the abnormal ALL-1 genes, we cloned the ALL-1 rearrangements from two patients with trisomy 11. Characterization of the clones, together with Southern blot analysis, indicates that the ALL-1 rearrangement in both patients is the result of a direct tandem duplication of a portion of the ALL-1 gene spanning exons 2-6. The partial ALL-1 duplication is also detected by Southern blot analysis in a patient with a normal karyotype. RNA PCR and DNA sequence analysis show that the partially duplicated ALL-1 gene is transcribed into mRNA capable of encoding a partially duplicated protein. Partial duplication of ALL-1, in which a portion of a putative protooncogene is fused with itself, represents an additional genetic mechanism for leukemogenesis. Our findings suggest that the presence of trisomy in malignancy may sometimes indicate the partial duplication of a cellular protooncogene. | lld:pubmed |
| pubmed-article:8016145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8016145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8016145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8016145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8016145 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8016145 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:CroceC MCM | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:BloomfieldC... | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:CanaaniEE | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:SchichmanS... | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:StruseT BTB | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:FOXJ NJN | lld:pubmed |
| pubmed-article:8016145 | pubmed:author | pubmed-author:CaligiuriM... | lld:pubmed |
| pubmed-article:8016145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8016145 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:8016145 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8016145 | pubmed:geneSymbol | MLL | lld:pubmed |
| pubmed-article:8016145 | pubmed:geneSymbol | HRX | lld:pubmed |
| pubmed-article:8016145 | pubmed:geneSymbol | ALL-1 | lld:pubmed |
| pubmed-article:8016145 | pubmed:geneSymbol | Htrx | lld:pubmed |
| pubmed-article:8016145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8016145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8016145 | pubmed:pagination | 6236-9 | lld:pubmed |
| pubmed-article:8016145 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:meshHeading | pubmed-meshheading:8016145-... | lld:pubmed |
| pubmed-article:8016145 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8016145 | pubmed:articleTitle | ALL-1 partial duplication in acute leukemia. | lld:pubmed |
| pubmed-article:8016145 | pubmed:affiliation | Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107. | lld:pubmed |
| pubmed-article:8016145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8016145 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8016145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8016145 | lld:pubmed |
