|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
1994-7-28
|
|
pubmed:abstractText |
The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations present in 5-10% of human acute leukemias. We have recently reported the detection by Southern blot of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations. These include 2 of 19 patients with normal karyotypes as well as 3 of 4 patients with trisomy 11. To characterize the abnormal ALL-1 genes, we cloned the ALL-1 rearrangements from two patients with trisomy 11. Characterization of the clones, together with Southern blot analysis, indicates that the ALL-1 rearrangement in both patients is the result of a direct tandem duplication of a portion of the ALL-1 gene spanning exons 2-6. The partial ALL-1 duplication is also detected by Southern blot analysis in a patient with a normal karyotype. RNA PCR and DNA sequence analysis show that the partially duplicated ALL-1 gene is transcribed into mRNA capable of encoding a partially duplicated protein. Partial duplication of ALL-1, in which a portion of a putative protooncogene is fused with itself, represents an additional genetic mechanism for leukemogenesis. Our findings suggest that the presence of trisomy in malignancy may sometimes indicate the partial duplication of a cellular protooncogene.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1303259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1423624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1423625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1438235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1617652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1720549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1835902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1931026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-1957167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-3120312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-3494520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8242616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8275471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8327517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8353274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8361504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8414510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8443374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8016145-8506309
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
91
|
|
pubmed:geneSymbol |
ALL-1,
HRX,
Htrx,
MLL
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6236-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8016145-Acute Disease,
pubmed-meshheading:8016145-Adult,
pubmed-meshheading:8016145-Base Sequence,
pubmed-meshheading:8016145-Blotting, Southern,
pubmed-meshheading:8016145-Chromosome Mapping,
pubmed-meshheading:8016145-Chromosomes, Human, Pair 11,
pubmed-meshheading:8016145-DNA Primers,
pubmed-meshheading:8016145-Gene Rearrangement,
pubmed-meshheading:8016145-Humans,
pubmed-meshheading:8016145-Introns,
pubmed-meshheading:8016145-Karyotyping,
pubmed-meshheading:8016145-Leukemia, Myeloid,
pubmed-meshheading:8016145-Molecular Sequence Data,
pubmed-meshheading:8016145-Multigene Family,
pubmed-meshheading:8016145-Polymerase Chain Reaction,
pubmed-meshheading:8016145-Restriction Mapping,
pubmed-meshheading:8016145-Trisomy
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
ALL-1 partial duplication in acute leukemia.
|
|
pubmed:affiliation |
Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
