Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-7-22
|
| pubmed:abstractText |
The age-related decline in spontaneous growth hormone (GH) secretion has been suggested to cause growth failure in girls with Turner syndrome (TS). We studied 23 girls (mean age +/- SD: 11.1 +/- 2.7 years) diagnosed to have TS by karyotype analysis. The control group consisted of 18 prepubertal age-matched subjects (10.7 +/- 2.5 years) with growth retardation due to familial short stature and/or constitutional growth delay. In addition, 18 children (10.9 +/- 3.3 years) diagnosed to have GH deficiency by two different provocative tests were chosen as a further comparison group. Spontaneous 12-hour nocturnal GH secretion was assessed by RIA at 30-min intervals. Plasma insulin-like growth factor 1 (IGF-1) levels were determined by RIA after acid-ethanol extraction. Girls with TS had a percentage of ideal body weight significantly higher than controls (p < 0.0001) and showed spontaneous GH secretion significantly lower than controls (mean +/- SD: 3.2 +/- 1.6 in TS vs. 5.5 +/- 1.3 microgram/l in controls; p < 0.0001) but higher than GH-deficient patients (1.3 +/- 0.8 microgram/l; p < 0.0001). No significant difference was found in IGF-1 levels between TS patients and controls, whereas GH-deficient children showed IGF-1 levels significantly lower than those of TS patients (p < 0.0005). As expected, GH concentrations correlated with bone age in controls (r = 0.51, p < 0.05), whereas no relationship was seen in TS. interestingly, in TS, GH levels were negatively related to the percentage of ideal body weight (r = -0.43, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0163
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
27-32
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8013939-Adolescent,
pubmed-meshheading:8013939-Age Determination by Skeleton,
pubmed-meshheading:8013939-Aging,
pubmed-meshheading:8013939-Body Weight,
pubmed-meshheading:8013939-Child,
pubmed-meshheading:8013939-Female,
pubmed-meshheading:8013939-Growth Disorders,
pubmed-meshheading:8013939-Growth Hormone,
pubmed-meshheading:8013939-Humans,
pubmed-meshheading:8013939-Insulin-Like Growth Factor I,
pubmed-meshheading:8013939-Obesity,
pubmed-meshheading:8013939-Puberty,
pubmed-meshheading:8013939-Turner Syndrome
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Reduced growth hormone secretion in Turner syndrome: is body weight a key factor?
|
| pubmed:affiliation |
Department of Paediatrics, Tor Vergata University, Rome, Italy.
|
| pubmed:publicationType |
Journal Article
|