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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2 Pt 1
|
| pubmed:dateCreated |
1994-7-22
|
| pubmed:abstractText |
Endosonography, which provides high-resolution images of the esophageal wall, could potentially detect carcinoma not visible endoscopically in patients with Barrett's esophagus and high-grade dysplasia. We studied the ability of endosonography to detect early esophageal carcinoma in 9 patients with Barrett's esophagus and high-grade dysplasia who were candidates for esophagectomy. Pre-operative endoscopy and biopsy revealed high-grade dysplasia without evidence of carcinoma in all patients. Pre-operative endosonographic evaluations were compared to the pathologic diagnoses of resected specimens. Post-operatively, 3 of the 9 patients were found to have intra-mucosal carcinoma. Endosonography identified a tumor in only 1 of these 3 patients and over-staged it as invasive carcinoma (T2, N1). In 2 of the 6 patients without intra-mucosal carcinoma, endosonography predicted invasive carcinoma (T2, N0). Endoscopy revealed mucosal nodularity in each of the 3 over-staged patients. We conclude that recommendation of the routine use of endosonography to determine the need for surgery in patients with Barrett's esophagus and high-grade dysplasia would be premature, because the current generation of echo-endoscopes does not reliably differentiate between benign and malignant wall thickening.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0016-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
207-12
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8013823-Adenocarcinoma,
pubmed-meshheading:8013823-Aged,
pubmed-meshheading:8013823-Barrett Esophagus,
pubmed-meshheading:8013823-Esophageal Neoplasms,
pubmed-meshheading:8013823-Esophagectomy,
pubmed-meshheading:8013823-Esophagoscopy,
pubmed-meshheading:8013823-Esophagus,
pubmed-meshheading:8013823-Humans,
pubmed-meshheading:8013823-Male,
pubmed-meshheading:8013823-Ultrasonography
|
| pubmed:articleTitle |
Endosonography in the evaluation of patients with Barrett's esophagus and high-grade dysplasia.
|
| pubmed:affiliation |
Department of Gastroenterology, Cleveland Clinic Foundation, OH 44195.
|
| pubmed:publicationType |
Journal Article
|