Linked Life Data

8012930

Source:http://linkedlifedata.com/resource/pubmed/id/8012930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-7-25
pubmed:abstractText
Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal transduction initiation of cell growth. To study the potential regulation of these two prominent human proto-oncogenes by AAV, the expression of three marker coding sequences ligated 3' of the proto-oncogene promoters were observed. Demonstrated here, the AAV Rep78 gene product was able to down-regulate the human c-fos and c-myc proto-oncogene promoters in all three assay systems. These interactions may partially explain AAVs anti-proliferation properties.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
81
pubmed:geneSymbol
c-fos, c-myc
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-36
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adeno-associated virus Rep78.
pubmed:affiliation
University of Arkansas for Medical Sciences, Department of Obstetrics and Gynecology, Little Rock 72205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.