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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6483
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pubmed:dateCreated |
1994-7-19
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pubmed:abstractText |
During positive selection, developing thymocytes are rescued from programmed cell death by T-cell receptor (TCR)-mediated recognition of major histocompatibility complex (MHC) molecules. MHC-bound peptides contribute to this process. Recently we identified individual MHC-binding peptides which can induce positive selection of a single TCR. Here we examine peptide fine specificity in positive selection. These data suggest that a direct TCR-peptide interaction occurs during this event, and strengthens the correlation between selecting peptides and TCR antagonists. Certain positively selecting peptides are weakly antigenic. We demonstrate that thymocytes 'educated' on such a peptide are specifically non-responsive to it and have decreased CD8 expression levels. Similar reduction of CD8 expression on mature T cells converts a TCR agonist into a TCR antagonist. These data indicate that thymocytes may maintain self-tolerance towards a positively selecting ligand by regulating co-receptor expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1286065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1386962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1532412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1617724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1834543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-1972592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2112266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2124002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2139497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2304556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2317862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-2961215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8124708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8128249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8305133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8417115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8478616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8496675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8008067-8500174
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
369
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
750-2
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:8008067-Amino Acid Sequence,
pubmed-meshheading:8008067-Animals,
pubmed-meshheading:8008067-Antigens, CD8,
pubmed-meshheading:8008067-Cell Differentiation,
pubmed-meshheading:8008067-Clone Cells,
pubmed-meshheading:8008067-Immune Tolerance,
pubmed-meshheading:8008067-Mice,
pubmed-meshheading:8008067-Mice, Transgenic,
pubmed-meshheading:8008067-Molecular Sequence Data,
pubmed-meshheading:8008067-Organ Culture Techniques,
pubmed-meshheading:8008067-Ovalbumin,
pubmed-meshheading:8008067-Peptide Fragments,
pubmed-meshheading:8008067-Receptors, Antigen, T-Cell,
pubmed-meshheading:8008067-T-Lymphocytes,
pubmed-meshheading:8008067-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8008067-Thymus Gland
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pubmed:year |
1994
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pubmed:articleTitle |
Specificity and flexibility in thymic selection.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle 98195.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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