Linked Life Data

8007462

Source:http://linkedlifedata.com/resource/pubmed/id/8007462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-7-21
pubmed:abstractText
Endothelins (ETs) are a family of peptides with potent constrictive activity in vascular and treacheal smooth muscle. The lung tissues are abundant in these peptides and their receptors; the peptides are produced by endothelial cells and airway epithelial cells, while its receptor is mainly located on smooth muscle. Therefore, it has been proposed that endothelins act in a paracrine fashion on nearby smooth muscle, thus regulating its tone. However, little is known about its physiological and pathological roles in pulmonary functions. We hypothesized that ET plays an important role in bronchoconstriction elicited by antigen challenge. In order to test this hypothesis, we investigated tracheal contractile activities and ET-receptors by employing an animal model in guinea pigs. Here, we report that guinea pigs who were sensitized followed by multiple challenges with the antigens had alterations of ET receptor(s) with respect to number and affinity.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0301-1542
pubmed:author
pubmed:issnType
Print
pubmed:volume
31 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
176-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Antigen-induced dynamic alterations of endothelin receptors--guinea pig lung tissues].
pubmed:affiliation
Department of Internal Medicine, University of Tsukuba, Ibarak, Japan.
pubmed:publicationType
Journal Article, In Vitro, English Abstract