pubmed-article:8006834 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C0027028 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C1882700 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C0014372 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C0034929 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
pubmed-article:8006834 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:8006834 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:8006834 | pubmed:dateCreated | 1994-7-20 | lld:pubmed |
pubmed-article:8006834 | pubmed:abstractText | 1. Mucosally added enterotoxin Escherichia coli STa increased the electrogenic Cl- secretion measured as the short-circuit current (Isc) across isolated muscle-stripped and muscle-unstripped rat mid-ilea incubated in vitro. 2. Pretreatment with serosal L-NAME (N omega-nitro-L-arginine methyl ester) or tetrodotoxin (TTX) significantly reduced the maximum Isc and the duration of action of STa in the unstripped but not stripped ilea. D-NAME (serosal), indomethacin or 5-hydroxy-tryptamine-desensitization was ineffective on STa-induced Isc in either stripped or unstripped ilea. 3. Serosal capsaicin reduced the maximum Isc of STa and its duration of action in unstripped ilea. 4. L-Arginine induced a significantly larger increase in the Isc across unstripped ilea than across stripped ilea; this could be significantly reduced by serosal L-NAME or TTX, although these were ineffective in stripped ilea. 5. Pretreatment of anaesthetized rats with I.P. L-NAME suppressed the fluid secretion induced by luminal STa in ilea in vivo but had no effect on that induced by luminal carbachol. 6. Mucosal STa increased electrogenic Cl- secretion across intact rat ileum in vitro by activating a capsaicin-sensitive, nitric oxide-dependent myenteric plexus-mediated secretory reflex. The suppression by L-NAME of STa induced ileal fluid secretion in vivo probably involves the inhibition of this reflex. | lld:pubmed |
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pubmed-article:8006834 | pubmed:language | eng | lld:pubmed |
pubmed-article:8006834 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8006834 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:8006834 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8006834 | pubmed:month | Mar | lld:pubmed |
pubmed-article:8006834 | pubmed:issn | 0022-3751 | lld:pubmed |
pubmed-article:8006834 | pubmed:author | pubmed-author:LevinR JRJ | lld:pubmed |
pubmed-article:8006834 | pubmed:author | pubmed-author:RolfeVV | lld:pubmed |
pubmed-article:8006834 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8006834 | pubmed:day | 15 | lld:pubmed |
pubmed-article:8006834 | pubmed:volume | 475 | lld:pubmed |
pubmed-article:8006834 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8006834 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8006834 | pubmed:pagination | 531-7 | lld:pubmed |
pubmed-article:8006834 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:8006834 | pubmed:year | 1994 | lld:pubmed |
pubmed-article:8006834 | pubmed:articleTitle | Enterotoxin Escherichia coli STa activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum. | lld:pubmed |
pubmed-article:8006834 | pubmed:affiliation | Department of Biomedical Science, University of Sheffield. | lld:pubmed |
pubmed-article:8006834 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8006834 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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