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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-7-20
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pubmed:abstractText |
1. Mucosally added enterotoxin Escherichia coli STa increased the electrogenic Cl- secretion measured as the short-circuit current (Isc) across isolated muscle-stripped and muscle-unstripped rat mid-ilea incubated in vitro. 2. Pretreatment with serosal L-NAME (N omega-nitro-L-arginine methyl ester) or tetrodotoxin (TTX) significantly reduced the maximum Isc and the duration of action of STa in the unstripped but not stripped ilea. D-NAME (serosal), indomethacin or 5-hydroxy-tryptamine-desensitization was ineffective on STa-induced Isc in either stripped or unstripped ilea. 3. Serosal capsaicin reduced the maximum Isc of STa and its duration of action in unstripped ilea. 4. L-Arginine induced a significantly larger increase in the Isc across unstripped ilea than across stripped ilea; this could be significantly reduced by serosal L-NAME or TTX, although these were ineffective in stripped ilea. 5. Pretreatment of anaesthetized rats with I.P. L-NAME suppressed the fluid secretion induced by luminal STa in ilea in vivo but had no effect on that induced by luminal carbachol. 6. Mucosal STa increased electrogenic Cl- secretion across intact rat ileum in vitro by activating a capsaicin-sensitive, nitric oxide-dependent myenteric plexus-mediated secretory reflex. The suppression by L-NAME of STa induced ileal fluid secretion in vivo probably involves the inhibition of this reflex.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1330611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1336410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1346555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1356888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1381691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-1729436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-2411917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-26915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-2859551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-3278943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-3288903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-3392679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-3839715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-6110665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-7684113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-8436804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006834-8448009
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
475
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8006834-Animals,
pubmed-meshheading:8006834-Arginine,
pubmed-meshheading:8006834-Bacterial Toxins,
pubmed-meshheading:8006834-Electrophysiology,
pubmed-meshheading:8006834-Enterotoxins,
pubmed-meshheading:8006834-Escherichia coli,
pubmed-meshheading:8006834-Escherichia coli Proteins,
pubmed-meshheading:8006834-Histological Techniques,
pubmed-meshheading:8006834-Ileum,
pubmed-meshheading:8006834-Intestinal Mucosa,
pubmed-meshheading:8006834-Male,
pubmed-meshheading:8006834-Myenteric Plexus,
pubmed-meshheading:8006834-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:8006834-Nitric Oxide,
pubmed-meshheading:8006834-Rats,
pubmed-meshheading:8006834-Rats, Inbred Strains,
pubmed-meshheading:8006834-Reflex,
pubmed-meshheading:8006834-Serotonin,
pubmed-meshheading:8006834-Stimulation, Chemical,
pubmed-meshheading:8006834-Tetrodotoxin
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pubmed:year |
1994
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pubmed:articleTitle |
Enterotoxin Escherichia coli STa activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum.
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pubmed:affiliation |
Department of Biomedical Science, University of Sheffield.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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