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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1994-7-19
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pubmed:abstractText |
Using in situ hybridization techniques and RNase protection assays, type II collagen mRNA was transiently detected in the epidermis of chick embryonic skins during days 9-15 after fertilization, with a maximum expression at day 11. Immunohistochemical studies demonstrated that deposition of type II collagen was also transiently localized at the subepidermal region during days 10-15. Type II collagen gene and gene product concomitantly started to decline preferentially at the region where feather buds were being formed on day 12, and thereafter diminished at the region between feather buds. Using immunohistochemical methods, type II collagen was also detected in human fetal scalp skin at 17-23 fetal weeks at the subepidermal region, excluding the region beneath the hair follicles. These results indicate that the lack of type II collagen expression is related to the development of feather and hair at a certain stage of chick embryonic and human fetal skin development.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-202X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
958-62
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8006460-Animals,
pubmed-meshheading:8006460-Chick Embryo,
pubmed-meshheading:8006460-Collagen,
pubmed-meshheading:8006460-Embryonic and Fetal Development,
pubmed-meshheading:8006460-Fetus,
pubmed-meshheading:8006460-Gene Expression,
pubmed-meshheading:8006460-Humans,
pubmed-meshheading:8006460-Immunohistochemistry,
pubmed-meshheading:8006460-In Situ Hybridization,
pubmed-meshheading:8006460-Procollagen,
pubmed-meshheading:8006460-RNA, Messenger,
pubmed-meshheading:8006460-Skin
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pubmed:year |
1994
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pubmed:articleTitle |
Expression of type II collagen at the middle stages of chick embryonic and human fetal skin development.
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pubmed:affiliation |
Department of Ophthalmology, National Children's Hospital, Keio University School of Medicine, Tokyo.
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pubmed:publicationType |
Journal Article
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