Linked Life Data

8005676

Source:http://linkedlifedata.com/resource/pubmed/id/8005676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-7-20
pubmed:abstractText
Serum obtained from normal human subjects contains antibodies reactive in an enzyme-linked immunosorbent assay with the glucuronoxylomannan (GXM) of Cryptococcus neoformans. The frequency of occurrence of class-specific antibodies among normal subjects was 28% for immunoglobulin G (IgG), 98% for IgM, and 3% for IgA. Anti-GXM antibodies with kappa light chains occurred in 98% of normal subjects, while the occurrence of lambda light chains was 28%. Each of five subjects with high levels of anti-GXM IgG antibodies had readily detectable antibodies of the IgG2 isotype; two of the five subjects had readily detectable IgG1 antibody. An examination of sera from human immunodeficiency virus-infected patients showed that human immunodeficiency virus infection was accompanied by a significant decrease in the occurrence of IgM antibodies and anti-GXM antibodies with kappa light chains; these decreases occurred early in infection when CD4 counts were still > or = 500 cells per microliter. A slight but not statistically significant decrease in the occurrence of anti-GXM IgG antibodies was seen only in patients with CD4 levels of < 200 cells per microliter. Sera from normal subjects with high levels of anti-GXM IgG antibodies were examined to identify any contribution of the antibodies to complement activation or to opsonization of the yeast cells. An analysis of the kinetics for activation and binding of C3 to the yeast cell showed no pattern of quantitative or qualitative differences between sera with high or low levels of anti-GXM IgG antibodies. Phagocytosis studies showed that the naturally occurring IgG antibodies did not contribute to opsonization of the yeast cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-14275410, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1541548, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1583327, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1639481, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1831795, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1987064, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-1991837, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-2187813, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-236018, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-239050, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-2407651, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-2525113, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-2572650, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-2612053, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3043650, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3049374, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3125258, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3138176, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-331113, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3514450, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-3652522, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-4596700, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-4811791, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-5334249, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-573303, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-7014468, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-7022456, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-7068854, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-7216494, http://linkedlifedata.com/resource/pubmed/commentcorrection/8005676-8262630
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2857-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Occurrences, immunoglobulin classes, and biological activities of antibodies in normal human serum that are reactive with Cryptococcus neoformans glucuronoxylomannan.
pubmed:affiliation
Department of Microbiology, University of Nevada, Reno 89557.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't