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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-1-20
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pubmed:databankReference |
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pubmed:abstractText |
Parallel occurrences of evolutionary events in the haptoglobin gene clusters of rhesus monkeys and humans were studied. We found six different haplotypes among 11 individuals from two rhesus monkey families. The six haplotypes include two types of haptoglobin gene clusters: one type with a single gene and the other with two genes. DNA sequence analysis indicates that the one-gene and the two-gene clusters were both formed by unequal homologous crossovers between two genes of an ancestral three-gene cluster, near exon 5, the longest exon of the gene. This exon is also the location where a separate unequal homologous crossover occurred in the human lineage, forming the human two-gene haptoglobin gene cluster from an ancestral three-gene cluster. The occurrence of independent homologous unequal crossovers in rhesus monkey and in human within the same region of DNA suggests that the evolutionary history of the haptoglobin gene cluster in primates is the consequence of frequent homologous pairings facilitated by the longest and most conserved exon of the gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:geneSymbol |
HP,
HPR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
579-89
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8001969-Animals,
pubmed-meshheading:8001969-Base Sequence,
pubmed-meshheading:8001969-Biological Evolution,
pubmed-meshheading:8001969-Chromosome Mapping,
pubmed-meshheading:8001969-Conserved Sequence,
pubmed-meshheading:8001969-Crossing Over, Genetic,
pubmed-meshheading:8001969-DNA,
pubmed-meshheading:8001969-Exons,
pubmed-meshheading:8001969-Female,
pubmed-meshheading:8001969-Gene Conversion,
pubmed-meshheading:8001969-Haplotypes,
pubmed-meshheading:8001969-Haptoglobins,
pubmed-meshheading:8001969-Humans,
pubmed-meshheading:8001969-Macaca mulatta,
pubmed-meshheading:8001969-Male,
pubmed-meshheading:8001969-Molecular Sequence Data,
pubmed-meshheading:8001969-Multigene Family,
pubmed-meshheading:8001969-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8001969-Species Specificity
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pubmed:year |
1994
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pubmed:articleTitle |
Parallel evolutionary events in the haptoglobin gene clusters of rhesus monkey and human.
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pubmed:affiliation |
Department of Pathology, University of North Carolina at Chapel Hill 27599-7525.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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