| pubmed-article:8001824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C1336776 | lld:lifeskim |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8001824 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8001824 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8001824 | pubmed:dateCreated | 1995-1-23 | lld:pubmed |
| pubmed-article:8001824 | pubmed:abstractText | We have isolated and characterized single-amino-acid substitution mutants of RNA polymerase alpha subunit defective in CAP-dependent transcription at the lac promoter but not defective in CAP-independent transcription. Our results establish that (1) amino acids 258-265 of alpha constitute an "activation target" essential for CAP-dependent transcription at the lac promoter but not essential for CAP-independent transcription, (2) amino acid 261 is the most critical amino acid of the activation target, (3) amino acid 261 is distinct from the determinants for alpha-DNA interaction, and (4) the activation target may fold as a surface amphipathic alpha-helix. We propose a model for transcriptional activation at the lac promoter that integrates these and other recent results regarding transcriptional activation and RNA polymerase structure and function. | lld:pubmed |
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| pubmed-article:8001824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8001824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8001824 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8001824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8001824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8001824 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8001824 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:GoldfarbAA | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:TaniFF | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:EbrightR HRH | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:SeverinovKK | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:ChaitBB | lld:pubmed |
| pubmed-article:8001824 | pubmed:author | pubmed-author:FenyoDD | lld:pubmed |
| pubmed-article:8001824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8001824 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8001824 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:8001824 | pubmed:geneSymbol | rpoA | lld:pubmed |
| pubmed-article:8001824 | pubmed:geneSymbol | lac | lld:pubmed |
| pubmed-article:8001824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8001824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8001824 | pubmed:pagination | 3058-67 | lld:pubmed |
| pubmed-article:8001824 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8001824 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8001824 | pubmed:articleTitle | Location, structure, and function of the target of a transcriptional activator protein. | lld:pubmed |
| pubmed-article:8001824 | pubmed:affiliation | Department of Chemistry, Rutgers University, New Brunswick, New Jersey 08855. | lld:pubmed |
| pubmed-article:8001824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8001824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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