rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1995-1-26
|
pubmed:abstractText |
The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has permitted us to ask whether neurons expressing a given receptor project their axons to common glomeruli within the olfactory bulb. In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb. Moreover, the position of specific glomeruli is bilaterally symmetric and is constant in different individuals within a species. These data support a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set of glomeruli, such that the individual odorants would be associated with specific topographic patterns of activity within the olfactory bulb.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0092-8674
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
16
|
pubmed:volume |
79
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
981-91
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8001145-Animals,
pubmed-meshheading:8001145-Axons,
pubmed-meshheading:8001145-Female,
pubmed-meshheading:8001145-In Situ Hybridization,
pubmed-meshheading:8001145-Models, Neurological,
pubmed-meshheading:8001145-Nerve Tissue Proteins,
pubmed-meshheading:8001145-Neurons, Afferent,
pubmed-meshheading:8001145-Odors,
pubmed-meshheading:8001145-Olfactory Bulb,
pubmed-meshheading:8001145-Olfactory Marker Protein,
pubmed-meshheading:8001145-Perception,
pubmed-meshheading:8001145-RNA, Messenger,
pubmed-meshheading:8001145-Rats,
pubmed-meshheading:8001145-Rats, Sprague-Dawley,
pubmed-meshheading:8001145-Receptors, Odorant,
pubmed-meshheading:8001145-Synapses
|
pubmed:year |
1994
|
pubmed:articleTitle |
Topographic organization of sensory projections to the olfactory bulb.
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|