|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0011155,
umls-concept:C0017337,
umls-concept:C0019904,
umls-concept:C0026809,
umls-concept:C0033684,
umls-concept:C0162429,
umls-concept:C0205349,
umls-concept:C0220784,
umls-concept:C1555903,
umls-concept:C1709634,
umls-concept:C2353566
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1995-1-24
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|
pubmed:abstractText |
The beta-amyloid precursor protein (beta APP) gene of the mouse was disrupted by inserting into exon 2 a cassette containing a neomycin resistance gene and a putative transcription termination sequence. Contrary to expectation, brain and other tissues from mice homozygous for the insertion still contained beta APP-specific RNA, albeit at a level 5- to 10-fold lower than wild type and lacking the disrupted exon, which had been spliced out. The brain contained shortened beta APP-specific protein at a low level. Mutant mice were severely impaired in spatial learning and exploratory behavior and showed increased incidence of agenesis of the corpus callosum.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
|
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
79
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
755-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8001115-Amyloid beta-Protein Precursor,
pubmed-meshheading:8001115-Animals,
pubmed-meshheading:8001115-Base Sequence,
pubmed-meshheading:8001115-Behavior, Animal,
pubmed-meshheading:8001115-Brain,
pubmed-meshheading:8001115-Exons,
pubmed-meshheading:8001115-Exploratory Behavior,
pubmed-meshheading:8001115-Female,
pubmed-meshheading:8001115-Gene Expression,
pubmed-meshheading:8001115-Homozygote,
pubmed-meshheading:8001115-Learning,
pubmed-meshheading:8001115-Male,
pubmed-meshheading:8001115-Mice,
pubmed-meshheading:8001115-Mice, Mutant Strains,
pubmed-meshheading:8001115-Molecular Sequence Data,
pubmed-meshheading:8001115-Mutagenesis, Insertional,
pubmed-meshheading:8001115-RNA, Messenger,
pubmed-meshheading:8001115-Spatial Behavior
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|
pubmed:year |
1994
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|
pubmed:articleTitle |
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
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|
pubmed:affiliation |
Institut für Molekularbiologie I, Universität Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
