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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
Specific adhesion molecules stabilize the binding between lymphocytes and antigen bearing cells; this intercellular adhesion is vital to both the affector and effector phases of an immune response. It is not known whether adhesion molecules and their counter-receptors can form the cross-species interactions that will facilitate human T cell recognition of xenogeneic porcine target cells. In this report it is demonstrated that a higher proportion of mitogen-activated than of resting human lymphocytes adhere to cultured porcine renal epithelial cells. Furthermore, antibody blocking experiments demonstrated that at least part of this cell-cell binding is stabilized by the human adhesion molecules LFA-1 (lymphocyte function-associated antigen-1) and the alpha 4-containing integrins. It is possible that this capacity for cross-species adhesion will play a role during the cell-mediated rejection of clinical porcine xenografts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0966-3274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8000851-Animals,
pubmed-meshheading:8000851-Antibodies, Monoclonal,
pubmed-meshheading:8000851-Antigens, CD2,
pubmed-meshheading:8000851-Binding, Competitive,
pubmed-meshheading:8000851-Cell Adhesion,
pubmed-meshheading:8000851-Cell Adhesion Molecules,
pubmed-meshheading:8000851-Cells, Cultured,
pubmed-meshheading:8000851-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:8000851-Epithelial Cells,
pubmed-meshheading:8000851-Epithelium,
pubmed-meshheading:8000851-Humans,
pubmed-meshheading:8000851-Integrin alpha4,
pubmed-meshheading:8000851-Integrins,
pubmed-meshheading:8000851-Kidney,
pubmed-meshheading:8000851-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:8000851-Lymphocytes,
pubmed-meshheading:8000851-Swine,
pubmed-meshheading:8000851-Transplantation, Heterologous
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pubmed:year |
1994
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pubmed:articleTitle |
Xenotransplantation: an examination of the adhesive interactions between human lymphocytes and porcine renal epithelial cells.
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pubmed:affiliation |
Department of Surgery, University of Newcastle upon Tyne, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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