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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
1995-1-13
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pubmed:abstractText |
4-Phenyl-3-furoxancarbonitrile (2) affords nitric oxide under the action of thiol cofactors. Two principal products were isolated in the reaction with thiophenol: the phenylcyanoglyoxime (6) and 5-amino-3-phenyl-4-(phenylthio)isoxazole (7). Mechanisms which could account for the formation of these two products are discussed. Compound 2 is an efficient activator of the rat lung soluble guanylate cyclase, displays high vasodilatory activity on strips of rat thoracic aorta precontracted with noradrenaline, and is a potent inhibitor of platelet aggregation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4412-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7996554-5'-Guanylic Acid,
pubmed-meshheading:7996554-Animals,
pubmed-meshheading:7996554-Aorta, Thoracic,
pubmed-meshheading:7996554-Enzyme Activation,
pubmed-meshheading:7996554-Guanylate Cyclase,
pubmed-meshheading:7996554-Humans,
pubmed-meshheading:7996554-Lung,
pubmed-meshheading:7996554-Male,
pubmed-meshheading:7996554-Mass Spectrometry,
pubmed-meshheading:7996554-Nitric Oxide,
pubmed-meshheading:7996554-Norepinephrine,
pubmed-meshheading:7996554-Oxadiazoles,
pubmed-meshheading:7996554-Phenols,
pubmed-meshheading:7996554-Platelet Aggregation Inhibitors,
pubmed-meshheading:7996554-Rats,
pubmed-meshheading:7996554-Rats, Wistar,
pubmed-meshheading:7996554-Sulfhydryl Compounds,
pubmed-meshheading:7996554-Vasodilation,
pubmed-meshheading:7996554-Vasodilator Agents
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pubmed:year |
1994
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pubmed:articleTitle |
Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation.
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pubmed:affiliation |
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi, Torino, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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