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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-1-17
|
| pubmed:abstractText |
The Romano-Ward long-QT Syndrome (LQTS) is an autosomal dominant inherited trait characterized by prolonged QT interval on ECG, life-threatening arrhythmias, syncope, and sudden death in affected individuals. A gene responsible for this disorder has been shown to be linked to the Harvey ras-1 locus (H-ras-1) DNA marker on the short arm of chromosome 11 (11p) in 7 families. The purpose of this study was to determine, by analyzing 23 families with LQTS for linkage to chromosome 11p, whether evidence exists for more than one gene causing LQTS (ie, locus heterogeneity).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0009-7322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2635-44
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7994803-Base Sequence,
pubmed-meshheading:7994803-Chromosome Mapping,
pubmed-meshheading:7994803-Genes, ras,
pubmed-meshheading:7994803-Genetic Linkage,
pubmed-meshheading:7994803-Genetic Variation,
pubmed-meshheading:7994803-Humans,
pubmed-meshheading:7994803-Long QT Syndrome,
pubmed-meshheading:7994803-Molecular Sequence Data,
pubmed-meshheading:7994803-Oligonucleotide Probes,
pubmed-meshheading:7994803-Pedigree,
pubmed-meshheading:7994803-Tyrosine 3-Monooxygenase
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Evidence of genetic heterogeneity in Romano-Ward long QT syndrome. Analysis of 23 families.
|
| pubmed:affiliation |
Baylor College of Medicine, Department of Pediatrics, Houston, TX 77030.
|
| pubmed:publicationType |
Journal Article
|