pubmed-article:7992839 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0332437 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0206693 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:7992839 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:7992839 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:7992839 | pubmed:dateCreated | 1995-1-6 | lld:pubmed |
pubmed-article:7992839 | pubmed:abstractText | The histological hallmarks for the diagnosis of medullary breast cancer are circumscription, syncytial architecture, diffuse inflammatory infiltrate, and highly atypical nuclei. The biological and prognostic implication is a lower propensity to metastasize. We studied 19 medullary carcinomas for expression of the intercellular adhesion molecule-1 and lymphocyte-function-associated antigen-1, Neu differentiation factor, tumor necrosis factor-alpha, and the expression of HER-2/neu, HER-4, and HER-3 receptors. Our study revealed that all of the 19 medullary carcinomas expressed the intercellular adhesion molecule-1 and lymphocyte function associated antigen. Eighteen of 19 cancers expressed Neu differentiation factor and tumor necrosis factor-alpha. All medullary cancers expressed the HER-2/neu receptor, however, in the majority of the cases, the staining was confined to the cytoplasm. Only 4 of 12 cancers expressed HER-4 and none of the eight medullary cancers tested expressed HER-3. By comparison, in a control group of infiltrating ductal carcinomas, expression of intercellular adhesion molecule-1, lymphocyte function associated antigen-1, and Neu differentiation factor was positive in about 25 to 30% of the cases, HER-4 was expressed in 75% and HER-3 in 95% of the cases. Taken together, our observations suggest that the expression of intercellular adhesion molecule-1, lymphocyte function associated antigen, Neu differentiation factor, and tumor necrosis factor-alpha as factors that may affect the special morphology and the biological behavior that characterizes medullary carcinomas. | lld:pubmed |
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pubmed-article:7992839 | pubmed:language | eng | lld:pubmed |
pubmed-article:7992839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7992839 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:7992839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:7992839 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7992839 | pubmed:month | Dec | lld:pubmed |
pubmed-article:7992839 | pubmed:issn | 0002-9440 | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:PageD LDL | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:KaminskyD BDB | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:WenDD | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:YardenYY | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:HülâgüA CAC | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:BacusS SSS | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:ChinD MDM | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:ZelnickC RCR | lld:pubmed |
pubmed-article:7992839 | pubmed:author | pubmed-author:BenningtonJJ | lld:pubmed |
pubmed-article:7992839 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7992839 | pubmed:volume | 145 | lld:pubmed |
pubmed-article:7992839 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7992839 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7992839 | pubmed:pagination | 1337-48 | lld:pubmed |
pubmed-article:7992839 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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