Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5191
|
| pubmed:dateCreated |
1995-1-10
|
| pubmed:abstractText |
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear RNA editing controls the calcium permeability of these channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain. In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop." The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
266
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1709-13
|
| pubmed:dateRevised |
2007-3-19
|
| pubmed:meshHeading |
pubmed-meshheading:7992055-Alternative Splicing,
pubmed-meshheading:7992055-Amino Acid Sequence,
pubmed-meshheading:7992055-Animals,
pubmed-meshheading:7992055-Base Sequence,
pubmed-meshheading:7992055-Brain,
pubmed-meshheading:7992055-Cell Nucleus,
pubmed-meshheading:7992055-Exons,
pubmed-meshheading:7992055-Glutamic Acid,
pubmed-meshheading:7992055-Glycine,
pubmed-meshheading:7992055-Introns,
pubmed-meshheading:7992055-Kinetics,
pubmed-meshheading:7992055-Membrane Potentials,
pubmed-meshheading:7992055-Molecular Sequence Data,
pubmed-meshheading:7992055-Oocytes,
pubmed-meshheading:7992055-PC12 Cells,
pubmed-meshheading:7992055-Patch-Clamp Techniques,
pubmed-meshheading:7992055-RNA Editing,
pubmed-meshheading:7992055-Rats,
pubmed-meshheading:7992055-Rats, Wistar,
pubmed-meshheading:7992055-Receptors, AMPA,
pubmed-meshheading:7992055-Recombinant Proteins,
pubmed-meshheading:7992055-Xenopus
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.
|
| pubmed:affiliation |
Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|