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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
1995-1-11
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pubmed:abstractText |
In vitro T-cell receptor-induced programmed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant "type 1" lymphokines interferon gamma and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programmed cell death. In contrast, the "type 2" lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programmed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programmed cell death and their possible role in the pathogenesis of HIV infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1346269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1350984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1352911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1400587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1535084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1676268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1680134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1768967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1826050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1826261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1944559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1972679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1974564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-1979585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-2147950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-2521375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-2574188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-2783497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-6211202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-7903123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8095166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8096699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8097337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8102239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8113410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8228816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8235617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8325338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8363721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7991540-8450057
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11811-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7991540-Apoptosis,
pubmed-meshheading:7991540-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7991540-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7991540-Cells, Cultured,
pubmed-meshheading:7991540-Cytokines,
pubmed-meshheading:7991540-HIV,
pubmed-meshheading:7991540-HIV Seronegativity,
pubmed-meshheading:7991540-HIV Seropositivity,
pubmed-meshheading:7991540-Humans,
pubmed-meshheading:7991540-Influenza A virus,
pubmed-meshheading:7991540-Interferon-gamma,
pubmed-meshheading:7991540-Interleukins,
pubmed-meshheading:7991540-Lymphocyte Activation,
pubmed-meshheading:7991540-Models, Biological,
pubmed-meshheading:7991540-Recombinant Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.
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pubmed:affiliation |
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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