Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1995-1-12
pubmed:abstractText
Anti-idiotypic antibodies (anti-Id or Ab2) were generated in Balb/c mice against either mouse monoclonal or swine polyclonal antibodies (Ab1) to pseudorabies virus (PRV) antigens by conventional and sequential immunization methods. In the conventional method, one antibody preparation was repeatedly injected into the animals, whereas three anti-PRV antibody preparations were used alternately for the sequential immunization procedure. Anti-Ids were serologically characterized for possession of the Ab2s that detect shared idiotype (IdX) on antibodies to PRV antigens. Only the Ab2s that were generated by the sequential immunization method recognized the IdX present on murine and swine antibodies to PRV. The sequential immunization method described herein was anticipated to be helpful for generating virus specific Ab2s as candidates for serodiagnostic reagents or vaccines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0166-0934
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-13
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Anti-idiotypic antibodies generated by sequential immunization detect the shared idiotype on antibodies to pseudorabies virus antigens.
pubmed:affiliation
Virology Section, Animal Diseases Research Institute, Nepean, Ont., Canada.
pubmed:publicationType
Journal Article