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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-1-5
|
| pubmed:abstractText |
The P2-purinergic receptor antagonists suramin, cibacron blue and basilen blue, the latter two being isomers of reactive blue 2, were studied for their effects on sound-evoked responses from the cochlea (cochlear microphonic, CM; summating potential, SP; distortion product otoacoustic emissions, DPOAE) and auditory nerve (compound action potential, CAP). Local application of these compounds (10-1000 microM) into the cochlear perilymph was associated with concentration-dependent response alterations. Effects of suramin on cochlear responses were minimal: High-intensity SP was reduced slightly at concentrations > or = 330 microM without significant alterations in CM or DPOAEs. The amplitude of the auditory nerve CAP was suppressed and its latency increased at drug concentrations > or = 100 microM. Cibacron blue and basilen blue were of greater potency in their effects on cochlear and auditory nerve responses. DPOAEs were generally reduced, low-intensity SP was reduced and high-intensity SP was increased and CM was little affected at drug concentrations 100-1000 microM. The CAP was suppressed and its latency increased at concentrations > or = 33 microM. Effects of suramin were largely reversible; those associated with cibacron blue and basilen blue generally were not. To the extent that these drugs acted selectively as antagonists of ATP receptor-mediated activity, results support the hypothesis that endogenous ATP exerts profound actions at the level of the cochlea and the auditory nerve.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Cibacron Blue F 3GA,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P2 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Suramin,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0378-5955
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
181-8
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7982811-Action Potentials,
pubmed-meshheading:7982811-Adenosine Triphosphate,
pubmed-meshheading:7982811-Animals,
pubmed-meshheading:7982811-Cochlea,
pubmed-meshheading:7982811-Coloring Agents,
pubmed-meshheading:7982811-Dose-Response Relationship, Drug,
pubmed-meshheading:7982811-Electrophysiology,
pubmed-meshheading:7982811-Evoked Potentials, Auditory,
pubmed-meshheading:7982811-Female,
pubmed-meshheading:7982811-Guinea Pigs,
pubmed-meshheading:7982811-Male,
pubmed-meshheading:7982811-Otoacoustic Emissions, Spontaneous,
pubmed-meshheading:7982811-Protein Synthesis Inhibitors,
pubmed-meshheading:7982811-Purinergic P2 Receptor Antagonists,
pubmed-meshheading:7982811-Stereoisomerism,
pubmed-meshheading:7982811-Suramin,
pubmed-meshheading:7982811-Triazines,
pubmed-meshheading:7982811-Vestibulocochlear Nerve
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
ATP antagonists cibacron blue, basilen blue and suramin alter sound-evoked responses of the cochlea and auditory nerve.
|
| pubmed:affiliation |
Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|