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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-1-4
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pubmed:abstractText |
The in vitro effects of aspirin in different concentrations on malondialdehyde formation and on the activity of antioxidant and some metal-containing enzymes in rat liver homogenate and erythrocytes were studied. Aspirin showed a biphasic dependence on concentration: low concentrations (to 1.0 mM) stimulated the spontaneously formed malondialdehyde in the liver homogenate and the high concentration (5.0 mM) inhibited it; all aspirin concentrations tested had no effect on the liposomes; 5.0 mM aspirin inhibited the Fe(2+)-induced lipid peroxidation in the liver homogenate but had an opposite effect on the liposomes. Aspirin dose-dependently inhibited nitro-blue tetrazolium reduction and decreased deoxyribose degradation. The higher aspirin concentrations inhibited the activity of antioxidant and some metal-containing enzymes. It is suggested that these aspirin effects are determined by the aspirin-metal complexes formed rather than by aspirin itself.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribose,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrous Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroblue Tetrazolium,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:author |
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7981976-Animals,
pubmed-meshheading:7981976-Antioxidants,
pubmed-meshheading:7981976-Aspirin,
pubmed-meshheading:7981976-Deoxyribose,
pubmed-meshheading:7981976-Dose-Response Relationship, Drug,
pubmed-meshheading:7981976-Edetic Acid,
pubmed-meshheading:7981976-Enzymes,
pubmed-meshheading:7981976-Ferrous Compounds,
pubmed-meshheading:7981976-Free Radical Scavengers,
pubmed-meshheading:7981976-Lipid Peroxidation,
pubmed-meshheading:7981976-Liposomes,
pubmed-meshheading:7981976-Liver,
pubmed-meshheading:7981976-Male,
pubmed-meshheading:7981976-Malondialdehyde,
pubmed-meshheading:7981976-Nitroblue Tetrazolium,
pubmed-meshheading:7981976-Oxidation-Reduction,
pubmed-meshheading:7981976-Rats,
pubmed-meshheading:7981976-Rats, Wistar,
pubmed-meshheading:7981976-Reactive Oxygen Species,
pubmed-meshheading:7981976-Thiobarbituric Acid Reactive Substances
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pubmed:year |
1994
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pubmed:articleTitle |
In vitro effects of aspirin on malondialdehyde formation and on activity of antioxidant and some metal-containing enzymes.
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pubmed:affiliation |
Institute of Physiology, Bulgaria Academy of Sciences, Sofia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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