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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-1-5
|
| pubmed:abstractText |
Although both mean lipoprotein(a) [Lp(a)] concentration and national stroke prevalence estimates are consistently higher in American blacks than in whites, no information exists on the relationship of Lp(a) and stroke prevalence in African-Americans. Associations of Lp(a) with stroke or transient ischemic attack (TIA) are addressed in this report for 15,160 participants--4160 blacks and 11,000 whites--in the Atherosclerosis Risk in Communities (ARIC) Study. Lp(a) was measured in ARIC as its total protein component by double-antibody enzyme-linked immunosorbent assay (ELISA) for apo(a) detection. Self-reported stroke/TIA history was assessed as part of a standardized questionnaire, and resulted in age-adjusted stroke/TIA prevalences of 3.0% in blacks (n = 120) and 2.0% in whites (n = 222). Overall, mean Lp(a) protein levels were markedly higher for blacks than for whites (160.5 versus 81.6 micrograms/mL, respectively), and were statistically significantly higher among individuals reporting stroke/TIA history for both races (191.3 versus 159.6 micrograms/mL in blacks; 100.6 versus 81.2 micrograms/mL in whites). Multivariable logistic regression analysis for the association of Lp(a) protein with stroke/TIA status yielded a prevalence odds ratio (OR) (95% confidence intervals) of 1.17 (1.05, 1.30) overall (based on one standard deviation difference, 108.2 micrograms/mL, in Lp[a] protein). Race-specific ORs, after adjustment for the same covariates, were equivalent for blacks [OR = 1.17 (0.99, 1.39)] and whites [OR = 1.19 (1.04, 1.36)]. These data suggest that Lp(a) is an independent risk factor for stroke/TIA in both blacks and whites, and that the relative risk of stroke/TIA associated with Lp(a) protein does not vary by race.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1047-2797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
351-9
|
| pubmed:dateRevised |
2008-6-23
|
| pubmed:meshHeading |
pubmed-meshheading:7981841-African Americans,
pubmed-meshheading:7981841-Cerebrovascular Disorders,
pubmed-meshheading:7981841-Cohort Studies,
pubmed-meshheading:7981841-Confidence Intervals,
pubmed-meshheading:7981841-Cross-Sectional Studies,
pubmed-meshheading:7981841-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7981841-European Continental Ancestry Group,
pubmed-meshheading:7981841-Female,
pubmed-meshheading:7981841-Humans,
pubmed-meshheading:7981841-Ischemic Attack, Transient,
pubmed-meshheading:7981841-Lipoprotein(a),
pubmed-meshheading:7981841-Male,
pubmed-meshheading:7981841-Middle Aged,
pubmed-meshheading:7981841-Odds Ratio,
pubmed-meshheading:7981841-Prevalence,
pubmed-meshheading:7981841-Regression Analysis,
pubmed-meshheading:7981841-Risk,
pubmed-meshheading:7981841-Risk Factors,
pubmed-meshheading:7981841-United States
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: the ARIC Study. Atherosclerosis Risk in Communities.
|
| pubmed:affiliation |
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|