Linked Life Data

7981147

Source:http://linkedlifedata.com/resource/pubmed/id/7981147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-1-3
pubmed:abstractText
The introduction of Freund's complete adjuvant into footpads of mice leads to functional changes of the high endothelial venules (HEV) in the draining lymph nodes. Using an in vitro adhesion assay, increased binding of monocytes and dendritic cells could be seen. These effects are also seen after injection of high doses of INF-gamma. No changes in the expression of vascular addressins, VCAM-1, E selection or ICAM-1 could be observed but the binding of monocytes could be blocked with an antibody against Mac-1. Depletion studies have made it clear that macrophages in the lymph node are not directly involved in the activation of the HEV. The induction of additional adhesion mechanisms on HEV could be an efficient way to recruit inflammatory cells into the lymph node, thereby regulating the local immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1195-201
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Activation of high endothelial venules in peripheral lymph nodes. The involvement of interferon-gamma.
pubmed:affiliation
Department of Cell Biology and Immunology, Vrije Universiteit, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article