|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1995-1-3
|
|
pubmed:abstractText |
The expression of interleukin 10 (IL-10) mRNA in human malignant melanoma was investigated by reverse transcriptase polymerase chain reaction analysis. Selective expression of IL-10 mRNA in tissues of primary melanomas and melanoma metastases was found in comparison with normal skin. In addition, strong expression of IL-10 mRNA and of biologically active IL-10 was detected in 3 out of 13 melanoma cell lines. Normal melanocytes consistently expressed low levels of IL-10 mRNA but did not produce detectable IL-10 protein, nor did keratinocytes or fibroblasts. The production of biologically active IL-10 by melanoma cell lines suggests that IL-10 mRNA in melanoma lesions may derive at least in part from the tumour cells themselves. Tumour-infiltrating cells, however, could also be a source of IL-10 in melanoma tissues. The presence of IL-10 in melanoma lesions may contribute to the postulated 'paralysis' of an anti-melanoma immune response.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1330578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1356125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1450672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1502188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1607665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1730874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1737931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1842931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1847510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1925582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-1940799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-2173142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-2191681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-2785562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-5482583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8288894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8344757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8364905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8419468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8450029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8464888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7981073-8518548
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
70
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1182-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:7981073-Gene Expression,
pubmed-meshheading:7981073-Humans,
pubmed-meshheading:7981073-Interleukin-10,
pubmed-meshheading:7981073-Keratinocytes,
pubmed-meshheading:7981073-Melanoma,
pubmed-meshheading:7981073-Neoplasm Metastasis,
pubmed-meshheading:7981073-RNA, Messenger,
pubmed-meshheading:7981073-RNA, Neoplasm,
pubmed-meshheading:7981073-Skin,
pubmed-meshheading:7981073-Tumor Cells, Cultured
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Expression of interleukin 10 in human melanoma.
|
|
pubmed:affiliation |
Institute of Immunology, Free University of Berlin, Germany.
|
|
pubmed:publicationType |
Journal Article
|
