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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-12-22
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pubmed:abstractText |
Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues [Nle4, DPhe7]alpha-MSH (MT-I) and Ac-[Nle4,[formula: see text]alpha-MSH4-10-NH2 (MT-II) were undertaken to examine their respective properties on the human peripheral melanocyte melanocortin receptor, hMC1R. alpha-MSH was found to possess a binding IC50 value of 6.5 +/- 0.9 x 10(-9) M and cAMP EC50 value of 2.0 +/- 0.6 x 10(-9) M. MT-I possesses a binding IC50 value of 1.2 +/- 0.3 x 10(-9) M and a cAMP EC50 of 0.5 +/- 0.03 x 10(-9) M. MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Affinity Labels,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/MSH, 4-Nle-7-Phe-alpha-,
http://linkedlifedata.com/resource/pubmed/chemical/Melanocyte-Stimulating Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Corticotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Melanocortin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-MSH
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1137-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7980588-Affinity Labels,
pubmed-meshheading:7980588-Amino Acid Sequence,
pubmed-meshheading:7980588-Animals,
pubmed-meshheading:7980588-Binding, Competitive,
pubmed-meshheading:7980588-Biological Assay,
pubmed-meshheading:7980588-Cloning, Molecular,
pubmed-meshheading:7980588-Cyclic AMP,
pubmed-meshheading:7980588-Humans,
pubmed-meshheading:7980588-Kinetics,
pubmed-meshheading:7980588-L Cells (Cell Line),
pubmed-meshheading:7980588-Lizards,
pubmed-meshheading:7980588-Melanocyte-Stimulating Hormones,
pubmed-meshheading:7980588-Melanocytes,
pubmed-meshheading:7980588-Mice,
pubmed-meshheading:7980588-Molecular Sequence Data,
pubmed-meshheading:7980588-Peptide Fragments,
pubmed-meshheading:7980588-Peptides, Cyclic,
pubmed-meshheading:7980588-Ranidae,
pubmed-meshheading:7980588-Receptors, Corticotropin,
pubmed-meshheading:7980588-Receptors, Melanocortin,
pubmed-meshheading:7980588-Recombinant Proteins,
pubmed-meshheading:7980588-Skin,
pubmed-meshheading:7980588-Skin Physiological Phenomena,
pubmed-meshheading:7980588-Structure-Activity Relationship,
pubmed-meshheading:7980588-Transfection,
pubmed-meshheading:7980588-alpha-MSH
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pubmed:year |
1994
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pubmed:articleTitle |
Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.
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pubmed:affiliation |
Department of Chemistry, University of Arizona, Tucson 85721.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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