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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1994-11-30
|
| pubmed:abstractText |
Polymorphonuclear neutrophil (PMN) priming appears to be an important event in the pathogenesis of hyperinflammatory states, resulting in adult respiratory distress syndrome or multiple organ failure. Interleukin-6 (IL-6) is an integral mediator of the acute stress response to injury and infection, but excessive and prolonged systemic levels have been associated with morbidity and mortality following trauma, burns, and elective surgery. We hypothesized that IL-6 primed PMNs for exaggerated cytotoxicity. However, we have been unable to directly prime PMNs for superoxide release with IL-6.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0004-0010
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
129
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1131-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7979944-Analysis of Variance,
pubmed-meshheading:7979944-Dose-Response Relationship, Drug,
pubmed-meshheading:7979944-Drug Synergism,
pubmed-meshheading:7979944-Humans,
pubmed-meshheading:7979944-Interleukin-6,
pubmed-meshheading:7979944-Neutrophils,
pubmed-meshheading:7979944-Platelet Activating Factor,
pubmed-meshheading:7979944-Recombinant Proteins,
pubmed-meshheading:7979944-Reference Values,
pubmed-meshheading:7979944-Time Factors
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Interleukin-6 potentiates neutrophil priming with platelet-activating factor.
|
| pubmed:affiliation |
Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|