Linked Life Data

7979189

Source:http://linkedlifedata.com/resource/pubmed/id/7979189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4A
pubmed:dateCreated
1994-12-23
pubmed:abstractText
Chemotherapy results in glioma are poor. In addition to chemotherapy most patients are treated with dexamethasone (Dex) to reduce brain edema. Therefore we examined the influence of Dex on the sensitivity of C6 glioma cells to methotrexate (MTX) using MTT-tests. The LD50 of MTX was 3*10(-8)M, 10(-7)M, 4*10(-6)M and 4*10(-4)M after 72, 24, 6 and 1 hour treatment, respectively. After incubations with combinations of Dex and MTX, twice as many cells survived high MTX concentrations. This protection could be overcome by addition of 10 to 100 fold more MTX. It was not species-specific since the effect was also found in human TE671 cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1585-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Dexamethasone induced partial resistance to methotrexate in C6-glioma cells.
pubmed:affiliation
Department of Pediatric Oncology, University Hospital of Münster, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't