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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-12-28
|
| pubmed:abstractText |
The scalp electroencephalogram (EEG), the long latency cognitive P300 auditory evoked response (AER), and reaction times were recorded in 10 volunteers sedated with a computer-controlled infusion of propofol to target plasma concentrations of 0.3, 0.6, 0.9, and 1.2 micrograms/mL. The observed mean +/- SE venous plasma concentrations were 0.152 +/- 0.042, 0.372 +/- 0.078, 0.679 +/- 0.104, and 1.065 +/- 0.112 micrograms/mL, respectively. Scalp EEG topographic mapping revealed that beta 1 activation was primarily frontal and central with relative sparing of the temporal lobes. The P300 response was dramatically reduced by propofol in a concentration-dependent manner, even though the subjects were conscious but clearly sedated. Mean +/- SE reaction times were increased by propofol sedation from 347 +/- 35 ms (control) to 391 +/- 48, 460 +/- 70, 549 +/- 64, and 622 +/- 120 ms at increasing mean venous plasma propofol concentrations. The mean percentage +/- SE of correct responses decreased from 98.1 +/- 2.0 (control) to 99.1 +/- 1.7, 87.4 +/- 9.2, 82.8 +/- 12.9, and 69.8 +/- 20.9 at increasing propofol concentrations. Dramatic alterations in the EEG, P300 response, and reaction times were observed, especially with the higher plasma concentrations which produced conscious sedation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0003-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1151-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7978441-Adult,
pubmed-meshheading:7978441-Beta Rhythm,
pubmed-meshheading:7978441-Conscious Sedation,
pubmed-meshheading:7978441-Dose-Response Relationship, Drug,
pubmed-meshheading:7978441-Electrophysiology,
pubmed-meshheading:7978441-Evoked Potentials, Auditory,
pubmed-meshheading:7978441-Female,
pubmed-meshheading:7978441-Humans,
pubmed-meshheading:7978441-Infusions, Intravenous,
pubmed-meshheading:7978441-Male,
pubmed-meshheading:7978441-Propofol
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Electrophysiologic effects of propofol sedation.
|
| pubmed:affiliation |
Department of Anesthesiology, University of Michigan, Ann Arbor 48109-0630.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|