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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-12-7
|
| pubmed:abstractText |
Cancer is caused by the accumulation of mutations that activate proto-oncogenes and inactivate tumor suppressor genes. The result is a clonal expansion of genetically identical daughter cells that eventually become clinical malignancies. The specific mutations acquired by the progenitor cell are like a fingerprint carried by each cell of the tumor. These mutations can serve as very specific markers for the presence of tumor cells in a background of normal cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9610
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
168
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
429-32
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7977967-Carcinoma, Squamous Cell,
pubmed-meshheading:7977967-DNA Mutational Analysis,
pubmed-meshheading:7977967-Genes, p53,
pubmed-meshheading:7977967-Genetic Markers,
pubmed-meshheading:7977967-Head and Neck Neoplasms,
pubmed-meshheading:7977967-Humans,
pubmed-meshheading:7977967-Nucleic Acid Hybridization,
pubmed-meshheading:7977967-Point Mutation,
pubmed-meshheading:7977967-Polymerase Chain Reaction,
pubmed-meshheading:7977967-Saliva,
pubmed-meshheading:7977967-Tumor Markers, Biological
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas.
|
| pubmed:affiliation |
Johns Hopkins Hospital, Department of Otolaryngology Head and Neck Surgery, Baltimore, Maryland 21287.
|
| pubmed:publicationType |
Journal Article
|