| pubmed-article:7977843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C0446377 | lld:lifeskim |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C2362312 | lld:lifeskim |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C0034787 | lld:lifeskim |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7977843 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7977843 | pubmed:issue | 5 Pt 2 | lld:pubmed |
| pubmed-article:7977843 | pubmed:dateCreated | 1994-12-8 | lld:pubmed |
| pubmed-article:7977843 | pubmed:abstractText | We reported previously that blood vessels of domestic fowl contain angiotensin (ANG) receptors on 1) endothelium, mediating vasorelaxation via endothelium-derived relaxing factor and guanosine 3',5'-cyclic monophosphate; 2) vascular smooth muscles, mediating neither relaxation nor contraction; and 3) presumably adrenergic nerve endings, transmitting vasopressor action via a release of norepinephrine. We aimed in the present study to determine fowl vascular ANG receptor subtypes and relate them to function. [Val5]ANG II (native fowl ANG II) increased mean arterial pressure of anesthetized, ganglion-blocker-treated fowl. The dose-pressor response curve for fowl ANG II was not altered by pretreatment (i.v.) with the ANG receptor subtype 1 (AT1) antagonist Dup-753 (losartan, 10 mg/kg) or the subtype 2 (AT2) antagonist PD-123319 (10 mg/kg). Furthermore, cumulative doses (1-20 mg/kg) of losartan or PD-123319 did not selectively inhibit ANG II-induced pressor responses. In reserpine- and prazosin-treated anesthetized fowl, [Val5]ANG II caused dose-dependent vasodepressor actions inhibited by neither losartan (10 mg/kg) nor PD-123319 (10 mg/kg). Likewise, [Val5]ANG II-induced vasorelaxation of fowl aortic rings in vitro was not inhibitable by PD-123319 or losartan (10(-5) M). Specific binding of 125I-labeled ANG II to the aortic endothelium was markedly displaced by ANG II, but not selectively by PD-123319 or losartan. Specific binding of 125I-ANG II ligand to the membrane fraction of aortic smooth muscles was displaced (50% inhibitory concentration) by [Val5]ANG II (3.3 x 10(-8) M) and slightly by PD-123319 (3.7 x 10(-5) M), but not by losartan or EXP-3174, an active metabolite of losartan.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7977843 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7977843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7977843 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7977843 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:ChiuA TAT | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:NishimuraHH | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:PattonC MCM | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:KeiserJJ | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:WalkerO EOE | lld:pubmed |
| pubmed-article:7977843 | pubmed:author | pubmed-author:MadisonA BAB | lld:pubmed |
| pubmed-article:7977843 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7977843 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:7977843 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7977843 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7977843 | pubmed:pagination | R1174-81 | lld:pubmed |
| pubmed-article:7977843 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7977843 | pubmed:meshHeading | pubmed-meshheading:7977843-... | lld:pubmed |
| pubmed-article:7977843 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7977843 | pubmed:articleTitle | Novel angiotensin receptor subtypes in fowl. | lld:pubmed |
| pubmed-article:7977843 | pubmed:affiliation | Department of Physiology and Biophysics, University of Tennessee, Memphis 38163. | lld:pubmed |
| pubmed-article:7977843 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7977843 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7977843 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7977843 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
