Linked Life Data

7977843

Source:http://linkedlifedata.com/resource/pubmed/id/7977843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1994-12-8
pubmed:abstractText
We reported previously that blood vessels of domestic fowl contain angiotensin (ANG) receptors on 1) endothelium, mediating vasorelaxation via endothelium-derived relaxing factor and guanosine 3',5'-cyclic monophosphate; 2) vascular smooth muscles, mediating neither relaxation nor contraction; and 3) presumably adrenergic nerve endings, transmitting vasopressor action via a release of norepinephrine. We aimed in the present study to determine fowl vascular ANG receptor subtypes and relate them to function. [Val5]ANG II (native fowl ANG II) increased mean arterial pressure of anesthetized, ganglion-blocker-treated fowl. The dose-pressor response curve for fowl ANG II was not altered by pretreatment (i.v.) with the ANG receptor subtype 1 (AT1) antagonist Dup-753 (losartan, 10 mg/kg) or the subtype 2 (AT2) antagonist PD-123319 (10 mg/kg). Furthermore, cumulative doses (1-20 mg/kg) of losartan or PD-123319 did not selectively inhibit ANG II-induced pressor responses. In reserpine- and prazosin-treated anesthetized fowl, [Val5]ANG II caused dose-dependent vasodepressor actions inhibited by neither losartan (10 mg/kg) nor PD-123319 (10 mg/kg). Likewise, [Val5]ANG II-induced vasorelaxation of fowl aortic rings in vitro was not inhibitable by PD-123319 or losartan (10(-5) M). Specific binding of 125I-labeled ANG II to the aortic endothelium was markedly displaced by ANG II, but not selectively by PD-123319 or losartan. Specific binding of 125I-ANG II ligand to the membrane fraction of aortic smooth muscles was displaced (50% inhibitory concentration) by [Val5]ANG II (3.3 x 10(-8) M) and slightly by PD-123319 (3.7 x 10(-5) M), but not by losartan or EXP-3174, an active metabolite of losartan.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
267
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1174-81
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:7977843-Acetylcholine, pubmed-meshheading:7977843-Angiotensin II, pubmed-meshheading:7977843-Angiotensin Receptor Antagonists, pubmed-meshheading:7977843-Animals, pubmed-meshheading:7977843-Aorta, Abdominal, pubmed-meshheading:7977843-Biphenyl Compounds, pubmed-meshheading:7977843-Blood Pressure, pubmed-meshheading:7977843-Cell Membrane, pubmed-meshheading:7977843-Chickens, pubmed-meshheading:7977843-Dose-Response Relationship, Drug, pubmed-meshheading:7977843-Endothelium, Vascular, pubmed-meshheading:7977843-Female, pubmed-meshheading:7977843-Imidazoles, pubmed-meshheading:7977843-Kinetics, pubmed-meshheading:7977843-Losartan, pubmed-meshheading:7977843-Models, Cardiovascular, pubmed-meshheading:7977843-Muscle, Smooth, Vascular, pubmed-meshheading:7977843-Muscle Contraction, pubmed-meshheading:7977843-Pyridines, pubmed-meshheading:7977843-Receptors, Angiotensin, pubmed-meshheading:7977843-Reserpine, pubmed-meshheading:7977843-Tetrazoles
pubmed:year
1994
pubmed:articleTitle
Novel angiotensin receptor subtypes in fowl.
pubmed:affiliation
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't