| pubmed-article:7977807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0740391 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7977807 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7977807 | pubmed:issue | 5 Pt 2 | lld:pubmed |
| pubmed-article:7977807 | pubmed:dateCreated | 1994-12-8 | lld:pubmed |
| pubmed-article:7977807 | pubmed:abstractText | Using microdialysis, we investigated the effect of hyperthermia on glutamate release in penumbral cortex of rats with 2 h of either normothermic (37 degrees C) or hyperthermic (39 degrees C) middle cerebral artery (MCA) occlusion. Penumbral blood flow (CBF) was measured by laser-Doppler flowmetry. CBF values (expressed as % preischemic values) in normothermic and hyperthermic groups were 24 +/- 11 (SD) and 24 +/- 16%, respectively, during ischemia and 102 +/- 81 and 147 +/- 79% during recirculation. Average extracellular glutamate in the hyperthermic group increased from a baseline of 7 +/- 2 microM to a peak of 217 +/- 184 microM at 10-20 min after onset of ischemia but returned to near baseline after 60 min. Glutamate in the normothermic group increased from 4 +/- 2 microM to a peak of 26 +/- 17 microM at 10-20 min after MCA occlusion but fell to near-baseline before recirculation. Thus reuptake systems appeared to remain functional in ischemic penumbra, even during hyperthermia. Ischemic glutamate release was significantly higher in hyperthermic than in normothermic rats: average values of individual rats' peak levels were 251 +/- 221 microM and 37 +/- 34 microM, respectively. The ischemic CBF threshold value for glutamate release was 33% of control in the normothermic group but 61% in the hyperthermic group. | lld:pubmed |
| pubmed-article:7977807 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7977807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977807 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7977807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7977807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7977807 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7977807 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7977807 | pubmed:author | pubmed-author:TakagiKK | lld:pubmed |
| pubmed-article:7977807 | pubmed:author | pubmed-author:GinsbergM DMD | lld:pubmed |
| pubmed-article:7977807 | pubmed:author | pubmed-author:MartinezEE | lld:pubmed |
| pubmed-article:7977807 | pubmed:author | pubmed-author:BustoRR | lld:pubmed |
| pubmed-article:7977807 | pubmed:author | pubmed-author:GlobusM YMY | lld:pubmed |
| pubmed-article:7977807 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7977807 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:7977807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7977807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7977807 | pubmed:pagination | H1770-6 | lld:pubmed |
| pubmed-article:7977807 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7977807 | pubmed:meshHeading | pubmed-meshheading:7977807-... | lld:pubmed |
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| pubmed-article:7977807 | pubmed:meshHeading | pubmed-meshheading:7977807-... | lld:pubmed |
| pubmed-article:7977807 | pubmed:meshHeading | pubmed-meshheading:7977807-... | lld:pubmed |
| pubmed-article:7977807 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7977807 | pubmed:articleTitle | Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats. | lld:pubmed |
| pubmed-article:7977807 | pubmed:affiliation | Department of Neurology, University of Miami School of Medicine, Florida 33101. | lld:pubmed |
| pubmed-article:7977807 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7977807 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7977807 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7977807 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7977807 | lld:pubmed |
