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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1994-12-7
|
| pubmed:abstractText |
The H2-antagonists famotidine and nizatidine produced a dose-dependent inhibition of histamine release from human colonic mucosal and muscle mast cells stimulated with anti-IgE. The IC30 values were in the range 0.5-10 microM and the maximum inhibition approached 50%. The compounds showed similar efficacy against rat peritoneal mast cells but were more potent. The cytoprotectant misoprostol had a striking effect on the human colonic mast cells, producing more than 50% inhibition at concentrations of 0.1-1 nM, but was much less active against the rat cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0065-4299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41 Spec No
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
C51-2
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:7976805-Animals,
pubmed-meshheading:7976805-Colon,
pubmed-meshheading:7976805-Famotidine,
pubmed-meshheading:7976805-Histamine H2 Antagonists,
pubmed-meshheading:7976805-Humans,
pubmed-meshheading:7976805-Mast Cells,
pubmed-meshheading:7976805-Misoprostol,
pubmed-meshheading:7976805-Nizatidine,
pubmed-meshheading:7976805-Peritoneal Cavity,
pubmed-meshheading:7976805-Rats
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Effects of the H2-antagonists famotidine and nizatidine and the cytoprotectant misoprostol on human colonic and rat peritoneal mast cells.
|
| pubmed:affiliation |
Department of Chemistry, University College London, UK.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|