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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
8086
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pubmed:dateCreated |
1978-10-25
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pubmed:abstractText |
30 patients with acute leukaemia being treated with cytotoxic drugs were investigated in a randomised trial to determine whether oral administration of co-trimoxazole in addition to non-absorbable antibiotics would reduce the rate of infection. Three significant differences were observed between the co-trmoxazole and the control groups: (i) 15 of the 16 (94%) control patients but only 8 of the 14 (57%) patients on co-trimoxazole developed infections and required additional antibiotics intravenously; (ii) although the duration of severe neutropenia (neutrophils less than 0.1 times 10(9)/1) was similar in the two groups, control patients required intravenous antibiotics on average after 2 days of neutropenia, whereas patients receiving co-trimoxazole required these only after 12 days; and (iii) the only 2 patients who died of infection were in the control group. Prophylaxis with co-trimoxazole is important in preventing or delaying the development of infection in neutropenic patients receiving therapy for acute leukaemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0140-6736
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
2
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
395-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:79761-Administration, Oral,
pubmed-meshheading:79761-Adolescent,
pubmed-meshheading:79761-Adult,
pubmed-meshheading:79761-Aged,
pubmed-meshheading:79761-Clinical Trials as Topic,
pubmed-meshheading:79761-Colistin,
pubmed-meshheading:79761-Cross Infection,
pubmed-meshheading:79761-Drug Combinations,
pubmed-meshheading:79761-Drug Therapy, Combination,
pubmed-meshheading:79761-Framycetin,
pubmed-meshheading:79761-Humans,
pubmed-meshheading:79761-Leukemia, Lymphoid,
pubmed-meshheading:79761-Leukemia, Myeloid, Acute,
pubmed-meshheading:79761-Middle Aged,
pubmed-meshheading:79761-Neutropenia,
pubmed-meshheading:79761-Nystatin,
pubmed-meshheading:79761-Prospective Studies,
pubmed-meshheading:79761-Research Design,
pubmed-meshheading:79761-Sulfamethoxazole,
pubmed-meshheading:79761-Trimethoprim
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pubmed:year |
1978
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pubmed:articleTitle |
Co-trimoxazole for prevention of infection in acute leukaemia.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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