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| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0332257 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7975258 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7975258 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7975258 | pubmed:dateCreated | 1994-12-12 | lld:pubmed |
| pubmed-article:7975258 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7975258 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7975258 | pubmed:abstractText | The 10A1 murine leukemia virus induces tumors that lack lineage-specific markers found on myeloid, T-cell, and B-cell lineages. Either erythroid or multipotent stem cells can have this phenotype; therefore we have used fluorescence-activated cell sorter analysis with either multipotent stem cell markers or markers found on lineage-restricted precursors to differentiate between these two possibilities. The results showed that tumors induced by 10A1 expressed multipotent stem cell markers as well as some lineage-restricted precursor markers. To further study the tumor phenotype, we analyzed total RNAs from 10A1-induced tumors by Northern blotting for c-kit, erythropoietin receptor, and T-cell gamma receptor mRNAs. Most of the tumors contained these mRNAs, which are characteristic of early hematopoietic cells. These results are consistent with the hypothesis that 10A1-induced tumor cells are early multipotent hematopoietic stem cells. Southern blot analysis revealed that 14 of 14 10A1-induced tumor cell DNAs examined contained MuLV integrations into the fli-1 gene. The results strongly suggested that promoter insertion into fli-1 is required for tumor formation. | lld:pubmed |
| pubmed-article:7975258 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7975258 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7975258 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7975258 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7975258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7975258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7975258 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7975258 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:7975258 | pubmed:author | pubmed-author:KellerJJ | lld:pubmed |
| pubmed-article:7975258 | pubmed:author | pubmed-author:ReidWW | lld:pubmed |
| pubmed-article:7975258 | pubmed:author | pubmed-author:OttD EDE | lld:pubmed |
| pubmed-article:7975258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7975258 | pubmed:volume | 205 | lld:pubmed |
| pubmed-article:7975258 | pubmed:geneSymbol | fli-1 | lld:pubmed |
| pubmed-article:7975258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7975258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7975258 | pubmed:pagination | 563-8 | lld:pubmed |
| pubmed-article:7975258 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7975258 | pubmed:meshHeading | pubmed-meshheading:7975258-... | lld:pubmed |
| pubmed-article:7975258 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7975258 | pubmed:articleTitle | 10A1 MuLV induces a murine leukemia that expresses hematopoietic stem cell markers by a mechanism that includes fli-1 integration. | lld:pubmed |
| pubmed-article:7975258 | pubmed:affiliation | Laboratory of Molecular Virology and Carcinogenesis, PRI/DynCorp, Inc., NCI-Frederick Cancer Research and Development Center, Maryland 21702-1201. | lld:pubmed |
| pubmed-article:7975258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7975258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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