| pubmed-article:7974803 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C1522668 | lld:lifeskim |
| pubmed-article:7974803 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7974803 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7974803 | pubmed:dateCreated | 1994-12-15 | lld:pubmed |
| pubmed-article:7974803 | pubmed:abstractText | We investigated the effect of recombinant tumor necrosis factor-alpha (rTNF-alpha) on the proliferative response of human umbilical vein endothelial cells (HUVEC) to normal human serum (NHS), in the absence or the presence of interferon (IFN)-gamma. rTNF-alpha significantly impaired NHS-stimulated HUVEC growth at a dose as low as 0.1 U/ml. The inhibitory effect of rTNF-alpha was dose-dependent up to 50-100 U/ml and was already evident after 2 h of incubation. Doses of rTNF-alpha in the range of 10 U/ml completely suppressed 3H-thymidine uptake stimulated by 7.5% NHS, and the effect was partially overcome by 10-20% NHS. rTNF-alpha was not cytotoxic at doses up to 1000 U/ml. rIFN-gamma was also effective in suppressing NHS-stimulated 3H-thymidine incorporation, and at low doses (0.1 U/ml) rIFN-gamma and rTFN-alpha showed an additive effect. The effect of TFN-alpha and IFN-gamma in antagonizing the proliferative response of vascular endothelium to the variety of growth factors contained in human serum could be relevant in a variety of pathologic conditions involving endothelium damage and proliferation. | lld:pubmed |
| pubmed-article:7974803 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7974803 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7974803 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7974803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7974803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7974803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7974803 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7974803 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7974803 | pubmed:issn | 0300-8916 | lld:pubmed |
| pubmed-article:7974803 | pubmed:author | pubmed-author:BottazzoG FGF | lld:pubmed |
| pubmed-article:7974803 | pubmed:author | pubmed-author:Pujol-Borrell... | lld:pubmed |
| pubmed-article:7974803 | pubmed:author | pubmed-author:BelfioreAA | lld:pubmed |
| pubmed-article:7974803 | pubmed:author | pubmed-author:MauerhoffTT | lld:pubmed |
| pubmed-article:7974803 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7974803 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:7974803 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:7974803 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7974803 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7974803 | pubmed:pagination | 301-5 | lld:pubmed |
| pubmed-article:7974803 | pubmed:dateRevised | 2008-12-12 | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:meshHeading | pubmed-meshheading:7974803-... | lld:pubmed |
| pubmed-article:7974803 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7974803 | pubmed:articleTitle | Growth inhibition of human endothelial cells by human recombinant tumor necrosis factor alpha and interferon-gamma. | lld:pubmed |
| pubmed-article:7974803 | pubmed:affiliation | Department of Immunology, University College and Middlesex School of Medicine, London, U.K. | lld:pubmed |
| pubmed-article:7974803 | pubmed:publicationType | Journal Article | lld:pubmed |
