Linked Life Data

7974342

Source:http://linkedlifedata.com/resource/pubmed/id/7974342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-12-6
pubmed:abstractText
A patient with a history of habitual abortion, deep venous thrombosis, thrombocytopenia, high titer IgG anticardiolipin antibodies and a clearly positive lupus anticoagulant, was treated during her seventh pregnancy with high-dose intravenous immunoglobulins (IVIg) from the third month onwards. Every month, a daily infusion of 400 mg immunoglobulins per kg body weight was given during five consecutive days. The patient's pregnancy ended preterm with a live birth, delivered by caesarian section because of a placental abruption. The 1070 g (P20-P25) weighing girl was in good health, apart from a bradycardia, due to dysfunction of the atrioventricular conduction. Each treatment with IVIg resulted in a slight reduction of both anticardiolipin antibodies and lupus anticoagulant levels and in an increase in platelet count. During the six-month observation period, a gradual decline in antiphospholipid antibodies and an increase in platelet count was found. The potential role of anti-idiotypic antibodies, present in the IVIg used for treatment, was studied. In vitro, IVIg were able to reduce the binding of the patient's anticardiolipin antibodies to cardiolipin coated microtiter plates. The presence of anti-idiotypic antibodies in IVIg was further documented by affinity chromatography and by realtime biospecific interaction analysis (BIA) on a BIA-core instrument. Affinity purified anticardiolipin antibodies were retarded on a column of insolubilized IVIg and a weak interaction was found between IVIg and affinity purified antiphospholipid antibodies, coupled to the BIA-core biosensor. In addition, the same technology revealed increased levels of anti-antiphospholipid antibodies in the patient's plasma following IVIg therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
741-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7974342-Adult, pubmed-meshheading:7974342-Antibodies, Anti-Idiotypic, pubmed-meshheading:7974342-Antibodies, Antiphospholipid, pubmed-meshheading:7974342-Antiphospholipid Syndrome, pubmed-meshheading:7974342-Aspirin, pubmed-meshheading:7974342-Chromatography, Affinity, pubmed-meshheading:7974342-Combined Modality Therapy, pubmed-meshheading:7974342-Dose-Response Relationship, Drug, pubmed-meshheading:7974342-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:7974342-Female, pubmed-meshheading:7974342-Humans, pubmed-meshheading:7974342-Immunoglobulins, Intravenous, pubmed-meshheading:7974342-Nadroparin, pubmed-meshheading:7974342-Platelet Count, pubmed-meshheading:7974342-Pregnancy, pubmed-meshheading:7974342-Pregnancy Complications, pubmed-meshheading:7974342-Treatment Outcome
pubmed:year
1994
pubmed:articleTitle
High-dose intravenous immunoglobulin treatment of a pregnant patient with an antiphospholipid syndrome: immunological changes associated with a successful outcome.
pubmed:affiliation
Center for Molecular and Vascular Biology, University of Leuven, Belgium.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't