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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5189
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pubmed:dateCreated |
1994-12-23
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pubmed:databankReference |
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pubmed:abstractText |
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, C,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monokines,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Xcl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/lymphotactin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1395-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7973732-Amino Acid Sequence,
pubmed-meshheading:7973732-Animals,
pubmed-meshheading:7973732-Base Sequence,
pubmed-meshheading:7973732-Calcium,
pubmed-meshheading:7973732-Cell Line,
pubmed-meshheading:7973732-Chemokine CCL4,
pubmed-meshheading:7973732-Chemokines, C,
pubmed-meshheading:7973732-Chemotaxis, Leukocyte,
pubmed-meshheading:7973732-Cytokines,
pubmed-meshheading:7973732-Hematopoietic Stem Cells,
pubmed-meshheading:7973732-Humans,
pubmed-meshheading:7973732-Lymphokines,
pubmed-meshheading:7973732-Macrophage Inflammatory Proteins,
pubmed-meshheading:7973732-Mice,
pubmed-meshheading:7973732-Mice, Inbred BALB C,
pubmed-meshheading:7973732-Molecular Sequence Data,
pubmed-meshheading:7973732-Monokines,
pubmed-meshheading:7973732-Recombinant Proteins,
pubmed-meshheading:7973732-Sequence Alignment,
pubmed-meshheading:7973732-Sialoglycoproteins,
pubmed-meshheading:7973732-Signal Transduction,
pubmed-meshheading:7973732-T-Lymphocyte Subsets
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pubmed:year |
1994
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pubmed:articleTitle |
Lymphotactin: a cytokine that represents a new class of chemokine.
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pubmed:affiliation |
Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.
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pubmed:publicationType |
Journal Article
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