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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5186
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pubmed:dateCreated |
1994-12-7
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pubmed:abstractText |
An activity in human cell extracts is described that repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Satellite,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acid Heteroduplexes,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
814-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7973637-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:7973637-Base Composition,
pubmed-meshheading:7973637-Base Sequence,
pubmed-meshheading:7973637-Carrier Proteins,
pubmed-meshheading:7973637-Cell Extracts,
pubmed-meshheading:7973637-Cell Line,
pubmed-meshheading:7973637-Colorectal Neoplasms,
pubmed-meshheading:7973637-DNA, Satellite,
pubmed-meshheading:7973637-DNA Repair,
pubmed-meshheading:7973637-DNA-Binding Proteins,
pubmed-meshheading:7973637-HeLa Cells,
pubmed-meshheading:7973637-Humans,
pubmed-meshheading:7973637-Molecular Sequence Data,
pubmed-meshheading:7973637-MutS Homolog 2 Protein,
pubmed-meshheading:7973637-Neoplasm Proteins,
pubmed-meshheading:7973637-Nuclear Proteins,
pubmed-meshheading:7973637-Nucleic Acid Heteroduplexes,
pubmed-meshheading:7973637-Proto-Oncogene Proteins,
pubmed-meshheading:7973637-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7973637-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
DNA loop repair by human cell extracts.
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pubmed:affiliation |
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
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pubmed:publicationType |
Journal Article
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