Linked Life Data

7972908

Source:http://linkedlifedata.com/resource/pubmed/id/7972908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-12-29
pubmed:abstractText
The effects of boron neutron capture irradiation employing either BPA or BSH as neutron capture agents has been assessed using the dorsal skin of Fischer 344 rats. Pharmacokinetic studies, using prompt gamma spectrometry, revealed comparable levels of boron-10 (10B) in blood and skin after the intravenous infusion of BSH (100 mg/kg body wt.). The 10B content of blood (12.0 +/- 0.5 micrograms/g) was slightly higher than that of skin (10.0 +/- 0.5 micrograms/g) after oral dosing with BPA. Biphasic skin reactions were observed after irradiation with the thermal neutron beam alone or in combination with BPA or BSH. The time of onset of the first phase of the skin reaction, moist desquamation, was approximately 2 weeks. The time at which the second-wave skin reaction, dermal necrosis, became evident was dose-related and occurred after a latent interval of > or = 24 weeks, well after the acute epithelial reaction had healed. The incidence of both phases of skin damage was also dose-related. The radiation doses required to produce skin damage in 50% of skin sites (ED50 values) were calculated from dose-effect curves and these values were used to determine relative biological effectiveness (RBE) and compound biological effectiveness (CBE) factors for both moist desquamation and dermal necrosis. It was concluded on the basis of these calculations that the microdistribution of the two neutron capture agents had a critical bearing on the overall biological effect after thermal neutron activation. BSH, which was possibly excluded from the cytoplasm of epidermal cells, had a low CBE factor value (0.56 +/- 0.06) while BPA, which may be selectively accumulated in epidermal cells had a very high CBE factor (3.74 +/- 0.7). For the dermal reaction, where vascular endothelial cells represent the likely target cell population, the CBE factor values were comparable, at 0.73 +/- 0.42 and 0.86 +/- 0.08 for BPA ad BSH, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0167-8140
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7972908-Administration, Oral, pubmed-meshheading:7972908-Animals, pubmed-meshheading:7972908-Borohydrides, pubmed-meshheading:7972908-Boron, pubmed-meshheading:7972908-Boron Compounds, pubmed-meshheading:7972908-Boron Neutron Capture Therapy, pubmed-meshheading:7972908-Dose-Response Relationship, Radiation, pubmed-meshheading:7972908-Endothelium, Vascular, pubmed-meshheading:7972908-Injections, Intravenous, pubmed-meshheading:7972908-Isotopes, pubmed-meshheading:7972908-Male, pubmed-meshheading:7972908-Phenylalanine, pubmed-meshheading:7972908-Radiation Dosage, pubmed-meshheading:7972908-Radiation Injuries, Experimental, pubmed-meshheading:7972908-Radiation-Sensitizing Agents, pubmed-meshheading:7972908-Rats, pubmed-meshheading:7972908-Rats, Inbred F344, pubmed-meshheading:7972908-Relative Biological Effectiveness, pubmed-meshheading:7972908-Skin, pubmed-meshheading:7972908-Skin Diseases, pubmed-meshheading:7972908-Spectrometry, Gamma, pubmed-meshheading:7972908-Sulfhydryl Compounds, pubmed-meshheading:7972908-Wound Healing
pubmed:year
1994
pubmed:articleTitle
Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium.
pubmed:affiliation
CRC Normal Tissue Radiobiological Research Group, University of Oxford, UK.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't