Linked Life Data

7972620

Source:http://linkedlifedata.com/resource/pubmed/id/7972620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-11-29
pubmed:abstractText
Earlier studies suggest that cardiovascular responses in the laboratory and in the field are likely to be related when the laboratory tasks involve active coping, when the field measure is taken continuously, and when there is allowance for the effects of autocorrelation and physical activity on the ambulant cardiovascular measure. These studies lead to the hypothesis that the hyperreactivity common to the laboratory and to the field has a beta-adrenergic basis. We examined the heart rate variability of 16 hyperreactive and 16 hyporeactive subjects over an 8-hour period while they were receiving either a placebo or a cardio-selective beta-blocking drug (Bisoprolol) in a double-blind crossover design. Subjects were classified on the basis of their heart rate and systolic blood pressure responses to a complex self-paced, reaction-time task. Response in the field was assessed from the standard deviation of the raw heart rate series, after allowance for the serial dependency in the data using autoregressive methods and, when allowance was made for physical activity, assessed from the muscle activity of the thigh. As predicted, on placebo hyperreactive subjects had markedly more variable heart rates, particularly when allowance was made for physical activity. Although not confirmed by a significant interaction effect, this difference largely disappeared under beta-blockade.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-3174
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The relationship between cardiovascular reactivity in the laboratory and heart rate response in real life: active coping and beta blockade.
pubmed:affiliation
Department of Psychology, St George's Hospital Medical School, University of London, England.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't