| pubmed-article:7972089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:7972089 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:7972089 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:7972089 | pubmed:dateCreated | 1994-12-27 | lld:pubmed |
| pubmed-article:7972089 | pubmed:abstractText | We report here that the intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought to prevail for TCR. The TCR of one clone (2C) binds an allogeneic class I MHC protein (Ld) in association with an alpha-ketoglutarate dehydrogenase nonapeptide (QLSPFPFDL, termed QL9) with an intrinsic affinity (intrinsic equilibrium association constant) of 1-2 x 10(7) M-1. The TCR of the other clone (4G3) binds a syngeneic class I MHC protein (Kb) in association with an ovalbumin octapeptide (SIINFEKL, termed pOV8) with an intrinsic affinity of 1.5 x 10(6) M-1. A comparison of the two clones, combined with current views of T-cell repertoire selection in the thymus, leads us to propose that TCR affinities are generally likely to be higher for allogeneic MHC-peptide complexes than for syngeneic MHC-peptide complexes. | lld:pubmed |
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| pubmed-article:7972089 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7972089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972089 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7972089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7972089 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7972089 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:PetersonP APA | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:EisenH NHN | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:JacksonMM | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:KageyamaSS | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:TsomidesT JTJ | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:BrunmarkAA | lld:pubmed |
| pubmed-article:7972089 | pubmed:author | pubmed-author:SykulevYY | lld:pubmed |
| pubmed-article:7972089 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7972089 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:7972089 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7972089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7972089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7972089 | pubmed:pagination | 11487-91 | lld:pubmed |
| pubmed-article:7972089 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7972089 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7972089 | pubmed:articleTitle | High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. | lld:pubmed |
| pubmed-article:7972089 | pubmed:affiliation | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139. | lld:pubmed |
| pubmed-article:7972089 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7972089 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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