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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1994-12-27
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pubmed:abstractText |
We report here that the intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought to prevail for TCR. The TCR of one clone (2C) binds an allogeneic class I MHC protein (Ld) in association with an alpha-ketoglutarate dehydrogenase nonapeptide (QLSPFPFDL, termed QL9) with an intrinsic affinity (intrinsic equilibrium association constant) of 1-2 x 10(7) M-1. The TCR of the other clone (4G3) binds a syngeneic class I MHC protein (Kb) in association with an ovalbumin octapeptide (SIINFEKL, termed pOV8) with an intrinsic affinity of 1.5 x 10(6) M-1. A comparison of the two clones, combined with current views of T-cell repertoire selection in the thymus, leads us to propose that TCR affinities are generally likely to be higher for allogeneic MHC-peptide complexes than for syngeneic MHC-peptide complexes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1315417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1331092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1465448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1606619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1718764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-1763329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-2123347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-233899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-2731965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-300293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-3260350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-3261634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-3263574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-6334855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-6607474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-7889394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-8124708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-8248240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7972089-8489008
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11487-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7972089-Amino Acid Sequence,
pubmed-meshheading:7972089-Animals,
pubmed-meshheading:7972089-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7972089-Histocompatibility Antigens Class I,
pubmed-meshheading:7972089-Ketoglutarate Dehydrogenase Complex,
pubmed-meshheading:7972089-Kinetics,
pubmed-meshheading:7972089-Mice,
pubmed-meshheading:7972089-Molecular Sequence Data,
pubmed-meshheading:7972089-Ovalbumin,
pubmed-meshheading:7972089-Peptides,
pubmed-meshheading:7972089-Protein Binding,
pubmed-meshheading:7972089-Receptors, Antigen, T-Cell
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pubmed:year |
1994
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pubmed:articleTitle |
High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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