| pubmed-article:7971974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7971974 | lifeskim:mentions | umls-concept:C0520484 | lld:lifeskim |
| pubmed-article:7971974 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:7971974 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7971974 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:7971974 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:7971974 | pubmed:dateCreated | 1994-12-12 | lld:pubmed |
| pubmed-article:7971974 | pubmed:abstractText | Successful induction of tolerance across disparate (discordant) species barriers could overcome the organ shortage that presently limits clinical transplantation. We demonstrate here that xenogeneic swine thymic transplants can induce tolerance to swine antigens in mice, while positively selecting functional host CD4+ T cells. Immunologically normal C57BL/10 mice were thymectomized and depleted of T and natural killer cells; then they received transplants of fetal pig thymus and liver fragments. Mature mouse CD4+ T cells developed in the pig thymus grafts and migrated to the periphery. Swine grafts grew markedly and no anti-pig IgG response was produced. Mixed lymphocyte reactions confirmed that the new T cells were functional and were tolerant to pig antigens. | lld:pubmed |
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| pubmed-article:7971974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7971974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7971974 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7971974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7971974 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7971974 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:GlaserR MRM | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:LeeL ALA | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:SachsD HDH | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:SykesMM | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:ArnJ SJS | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:SablinskiTT | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:GritschH AHA | lld:pubmed |
| pubmed-article:7971974 | pubmed:author | pubmed-author:SergioJ JJJ | lld:pubmed |
| pubmed-article:7971974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7971974 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:7971974 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7971974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7971974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7971974 | pubmed:pagination | 10864-7 | lld:pubmed |
| pubmed-article:7971974 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7971974 | pubmed:meshHeading | pubmed-meshheading:7971974-... | lld:pubmed |
| pubmed-article:7971974 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7971974 | pubmed:articleTitle | Specific tolerance across a discordant xenogeneic transplantation barrier. | lld:pubmed |
| pubmed-article:7971974 | pubmed:affiliation | Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129. | lld:pubmed |
| pubmed-article:7971974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7971974 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7971974 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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