Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1994-12-12
pubmed:abstractText
Successful induction of tolerance across disparate (discordant) species barriers could overcome the organ shortage that presently limits clinical transplantation. We demonstrate here that xenogeneic swine thymic transplants can induce tolerance to swine antigens in mice, while positively selecting functional host CD4+ T cells. Immunologically normal C57BL/10 mice were thymectomized and depleted of T and natural killer cells; then they received transplants of fetal pig thymus and liver fragments. Mature mouse CD4+ T cells developed in the pig thymus grafts and migrated to the periphery. Swine grafts grew markedly and no anti-pig IgG response was produced. Mixed lymphocyte reactions confirmed that the new T cells were functional and were tolerant to pig antigens.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-1346345, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-1533241, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-1972159, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-1972728, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-2139098, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-2142721, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-2321009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-2477484, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-2538552, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-7908768, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-8426108, http://linkedlifedata.com/resource/pubmed/commentcorrection/7971974-8436912
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10864-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Specific tolerance across a discordant xenogeneic transplantation barrier.
pubmed:affiliation
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't