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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1994-12-12
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pubmed:abstractText |
The hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor critically required for the function of the Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1). eIF-5A localizes in the nuclear and cytoplasmic compartments of mammalian cells, suggesting possible activities on the level of regulated mRNA transport and/or protein translation. In this report we show that eIF-5A gene expression is constitutively low but inducible with T-lymphocyte-specific stimuli in human peripheral blood mononuclear cells (PBMCs) of healthy individuals. In contrast, eIF-5A is constitutively expressed at high levels in human cell lines as well as in various human organs. Comparison of eIF-5A levels in the PBMCs of uninfected and HIV-1-infected donors shows a significant upregulation of eIF-5A gene expression in the PBMCs of HIV-1 patients, compatible with a possible role of eIF-5A in HIV-1 replication during T-cell activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1356123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1371954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1384058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1424273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1673030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1850732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-1949157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2119810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2312149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2369902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2458922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2492279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2509460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2509461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2536062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2687689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-2953813,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-459896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-592398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-6322116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-6332315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-6334364,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7971969-8347280
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10829-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7971969-Base Sequence,
pubmed-meshheading:7971969-Cell Division,
pubmed-meshheading:7971969-Cell Line,
pubmed-meshheading:7971969-Cells, Cultured,
pubmed-meshheading:7971969-DNA Primers,
pubmed-meshheading:7971969-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:7971969-Gene Expression,
pubmed-meshheading:7971969-HIV Infections,
pubmed-meshheading:7971969-Humans,
pubmed-meshheading:7971969-Lymphocyte Activation,
pubmed-meshheading:7971969-Lysine,
pubmed-meshheading:7971969-Molecular Sequence Data,
pubmed-meshheading:7971969-Peptide Chain Initiation, Translational,
pubmed-meshheading:7971969-Peptide Initiation Factors,
pubmed-meshheading:7971969-RNA, Messenger,
pubmed-meshheading:7971969-RNA-Binding Proteins,
pubmed-meshheading:7971969-T-Lymphocytes,
pubmed-meshheading:7971969-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.
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pubmed:affiliation |
Sandoz Research Institute, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro
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